Latin American telco America Movil has announced p

first_imgLatin American telco America Movil has announced plans to make a €7.2 billion bid for all issued and outstanding shares in KPN in the Netherlands.Mexican billionaire Carlos Slim’s America Movil already owns 30% of KPN and the new €2.40 per-share offer for the remaining 70% marks a 35.4% premium over the firm’s closing price in the last 30 days.In a statement, America Movil said it plans to buy the majority stake in the business to “facilitate greater operational cooperation and co-ordination between the two companies, to exploit all areas for potential partnerships and to intensify the realisation of synergy potential for both companies.”America Movil first bought into KPN more than a year ago and was its first investment outside the Americas as part of its efforts to “achieve geographical diversification and create attractive long-term returns for its shareholders.”The firm has since bought a minority stake in Telekom Austria and recently invested US$40 million (€46 million) in Second screen app and media recognition specialist Shazam.The KPN takeover bid comes after KPN announced last month that, subject to shareholder approval, it would sell its German subsidiary E-Plus to Telefonica Deutschland in exchange for €5 billion in cash and a 17.6% stake in Telefonica Deutschland.“América Móvil is carefully evaluating the merits of the proposed transaction and will make a final determination in relation to the exercise of its voting rights  at  the  upcoming Extraordinary General Meeting of KPN,” said America Movil.In a statement confirming America Movil’s planned offer, KPN said that it will “carefully consider” the intended bid and “expects to convene an extraordinary general meeting related to the sale of E-Plus to Telefónica Deutschland in the coming weeks.”America Movil said it intends to submit an offer memorandum to the Netherlands Authority for the Financial Markets, following which it will place its bid. It said it expects this to take place during September.last_img read more

Creating new environment to improve treatment for limbal stem cell deficiency

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 31 2018You’ve probably seen the late night ads and the onslaught of cosmetic marketing – hyaluronic acid or hyaluronan, touted as the “fountain of youth,” the best moisturizer or skin plumper on the market. It turns out, this naturally occurring molecule, with high concentrations in the eyes, is necessary for creating stem cells in the limbus, the border of the cornea and whites of the eye (sclera). Limbal stem cells regenerate the cornea after serious corneal injury. Patients who lack these cells and their environment develop a condition called limbal stem cell deficiency which causes opaque corneas.”Our hope is to use the knowledge of hyaluronan in creating stem cells to improve the treatment of patients with limbal stem cell deficiency,” said assistant professor of optometry Vivien Coulson-Thomas whose research is supported by a $1.9M grant from the National Eye Institute.She previously discovered that hyaluronan in the eyes is present exclusively in the corneal limbus.”This grant is to look at how the hyaluronan creates limbal stem cells and we will also look at whether we can take a cell, put it on a hyaluronan layer, or substrate, and create new stem cells in the lab,” said Coulson-Thomas.Stem cells, the body’s version of cells on reserve, exist in a nonspecific state until called upon to transform into the kind of cell that can produce new body tissue for either maintenance or to repair an injury. Every cell needs the proper environment to grow, and Coulson-Thomas is exploring what environment corneal stem cells need to do their job and then recreate that environment in patients where it has been damaged.Related StoriesNANOLIVE‘s novel CX-A defines a new standard for live cell imaging in 96 well plates for continuous organelle monitoring in cell populationsAbcam Acquire Off-The-Shelf Diploid Library of Over 2,800 Knockout Cell LinesSlug serves as ‘command central’ for determining breast stem cell health”The environment, called the extracellular matrix, can make a stem cell turn into something else. If you change the environment, you change the cell,” said Coulson-Thomson, who has studied the extracellular matrix for 20 years, one of the few researcher experts in this understudied field. The cell itself influences what is in the extracellular matrix and one of those things is hyaluronan.Substantial evidence shows that the cornea contains a limbal stem cell niche containing limbal stem cells, which are vital for reconstituting the corneal epithelium after injury. Injury to the cornea leading to substantial damage of the niche may decrease the overall number of limbal stem cells, reducing the ability of these cells to resurface the corneal epithelium. In severe cases this can lead to limbal stem cell deficiency, a serious medical condition.Even if a patient has a few remaining limbal stem cells, its extracellular matrix is filled with scar tissue, so the cells will not remain stem cells. Coulson-Thomas will explore increasing stem cells by determining the ideal substrate layer for their growth in a petri dish.”If you put the stem cells on plastic dishes with environments completely foreign to the cells, not all the cells will stay stem cells, they’re going to become other kinds of cells, and then who knows what kind of cells will eventually be put into a recipient,” said Coulson-Thomas. Her method to control the outcome includes expanding substrates with hyaluronan and then measuring the percentage of cells that remain stem cells. Source:http://www.uh.edu/news-events/stories/2018/october-2018/103018-coulson-thomas-corneal-stem-cells.phplast_img read more

Regenstrief scientist calls for precision surveillance for colon cancer screening

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 8 2018The interval at which an individual undergoes a repeat colonoscopy because of previous pre-cancerous polyps — a practice known as “surveillance” — should be tailored to the individual and not simply be determined by the results of prior colonoscopies, according to Regenstrief Institute research scientist Thomas F. Imperiale, M.D. In an editorial in the American Journal of Gastroenterology, he calls for “precision surveillance,” a phrase he has coined to echo the personalized, targeted focus of precision medicine and the application of these concepts to colon cancer screening and surveillance.”The goal of colorectal cancer surveillance is to reduce incidence and death from colorectal cancer,” said Dr. Imperiale. “The only factor we currently consider for whether and when to do a surveillance colonoscopy is the number and size of precancerous polyps found on a previous colonoscopy screening. No other factors are considered; this practice does not always make good clinical sense.”Precision surveillance goes beyond that one element (what’s in the colon) and considers the patient’s phenotype – personal characters such as age, personal medical history, BMI (body mass index), and health habits such as smoking. And when the data become more widely available, consideration of when to rescope should include the skill of the colonoscopists who performed the previous colonoscopies.”Dr. Imperiale says that his editorial, “Thinking Big About Small Adenomas: Moving Towards ‘Precision Surveillance'” is a small step toward advancing surveillance colonoscopy by expanding the proportion of persons considered “low-risk” from one or two small, precancerous polyps to up to four such polyps. The giant leap, he says, would be to employ precision surveillance and make screening recommendations truly personalized and based on the patient, their polyps, and their colonoscopist.Related StoriesAre physical examinations by family doctors still needed?Mosquito surveillance in Madagascar reveals new insight into malaria transmissionScientists discover hundreds of protein-pairs through coevolution studyAlthough studies suggest that the smaller the precancerous lesions are, the longer it takes for them to become cancerous, scientists do not have an accurate picture of the natural history of these lesions because they are removed upon discovery. It is known that most do not become cancerous.”While we want to keep an eye on those individuals who have shown they can grow precancerous polyps, we need to balance being appropriately aggressive in those with whom we should be, with backing off from intense treatment for people who don’t require it ,” said Dr. Imperiale. “Precision surveillance starts to get at that issue.”As an example, he contrasts two hypothetical patients — a healthy 55-year-old and a 70-year-old on home oxygen or dialysis. Each is found to have one or two small precancerous polyps. Current guidelines call for the same five- to ten-year interval for a repeat colonoscopy; most colonoscopists would re-scope at five years. Dr. Imperiale says that colonoscopists need to use their judgment and discuss with each patient when and even if to repeat the colonoscopy.For the 55-year-old he would recommend a repeat colonoscopy in five to ten years or sooner if symptoms appear or other concerns arise. For the 70-year-old with significant health issues he would discuss with the individual and relevant family whether the best course might be to forego further colonoscopy simply to look for any new polyps.”To provide the best care to patients and use healthcare resources responsibly, we need to be more thoughtful about certain factors in addition to the results of previous colonoscopies,” said Dr. Imperiale. “We need to screen and re-examine those who need it most and not those people who won’t benefit. Precision screening and surveillance may help achieve that goal.”Source: https://www.regenstrief.org/article/moving-towards-precision-surveillance/last_img read more

Research reveals how metabolites can be used to inhibit epigenetic mechanisms and

first_img Source:http://www.asrc.cuny.edu/ Reviewed by Alina Shrourou, B.Sc. (Editor)Feb 28 2019The discovery could lead to novel, more specific, and more effective MS therapies and a better understanding of how the disease developsUnderstanding and mitigating the role of epigenetics (environmental influences that trigger changes in gene expression) in disease development is a major goal of researchers. Now, a newly published paper featured on the March cover of the journal Brain adds significantly to this work by detailing how metabolites can be used to inhibit epigenetic mechanisms and effectively treat a range of diseases, including multiple sclerosis (MS).Dimethyl fumarate (Tecfidera™)–a cell-permeable metabolite in the family of fumaric acid esters (FAEs)–is an approved treatment for MS and is potentially an effective therapy for other autoimmune diseases. The precise mechanism of the drug’s action has been only partially understood, however. In their new paper, researchers at the Advanced Science Research Center (ASRC) at The Graduate Center of The City University of New York and the Icahn School of Medicine at Mount Sinai take a major step toward unraveling the mystery by identifying a possible mechanism of action for FAEs. In doing so, they also highlight new concepts that may lay the groundwork for the development of novel classes of drugs for the treatment of MS and other diseases.Scientists believe that MS develops when epigenetic changes cause certain brain-homing immune cells–or T cells–to attack the central nervous system. In their current paper, researchers posited that FAE metabolites work by mitigating the development of certain brain-homing T cells.”This work has given us extremely useful insight into how we might leverage the metabolic-epigenetic interplay between cells and their environment to create new immune-modulating therapies for diseases like MS,” said Patrizia Casaccia, director of the ASRC Neuroscience Initiative and a professor of genetics and neuroscience at Mount Sinai. “It may one day be possible to target and suppress production of the specific brain-homing T cells that play a role in the development of MS.”MethodologyRelated StoriesMercy Medical Center adds O-arm imaging system to improve spinal surgery resultsNew therapy shows promise in preventing brain damage after traumatic brain injuryRush University Medical Center offers new FDA-approved treatment for brain aneurysmsResearchers recruited 97 volunteers with MS that were either treatment-naïve (47), FAE-treated (35), or glatiramer acetate-treated (16). Blood samples were collected from each participant and their levels of brain-homing T cells were measured by looking at the percentages of the chemokine receptors CCR4 and CCR6, which are critical to T cell trafficking between the gut, brain, and skin. The data showed significantly lower levels of these brain-homing T cells in the FAE-treated group than in the other comparison groups.Researchers subsequently analyzed how FAEs change the epigenetic landscape of T cells to reduce the development of these pathogenic cells. Specifically, they found that FAEs have a strong epigenetic effect on a particular DNA region in T cells that includes a micro RNA called MIR-21, which is necessary to create disease-associated brain-homing T cells. Taken together, the results suggest that the immunomodulatory effect of FAEs in MS is at least in part due to the epigenetic regulation of these specific brain-homing T cells.Significance”Our findings about therapeutically active metabolites have implications for the treatment of not only multiple sclerosis but also other autoimmune diseases such as psoriasis and inflammatory bowel disease, which involve the same type of T cells,” said Achilles Ntranos, lead author of the paper and a physician and neuroimmunology fellow at Mount Sinai Hospital whose work is supported by the Leon Levy Foundation and the National Institute of Neurological Disorders and Strokes. “Understanding the epigenetic effect of metabolites on the immune system will help us develop several novel strategies for the treatment of autoimmune diseases, which could help patients and physicians achieve better clinical outcomes.”Organizational AttributionOur correct name is the Advanced Science Research Center at The Graduate Center of The City University of New York. For the purpose of space, Advanced Science Research Center, GC/CUNY is acceptable. On second reference, ASRC is correct.last_img read more

Uber resumes testing for autonomous cars in manual mode

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Uber said Tuesday it was taking the first step toward restarting its autonomous ridesharing program, putting its self-driving cars back on the road in “manual mode,” with a driver at the wheel at all times. Toyota suspends self-driving car tests after Uber death © 2018 AFP Uber, which suspended its autonomous car testing for four months following a fatal accident, says it will resume tests but with a driver at the wheel at all times, to gather data on safetycenter_img Citation: Uber resumes testing for autonomous cars in ‘manual mode’ (2018, July 24) retrieved 18 July 2019 from https://phys.org/news/2018-07-uber-resumes-autonomous-cars-manual.html The ridesharing giant said its specially equipped vehicles would be back in service for the first time since it suspended tests following a fatal accident in Arizona.”We’re starting with cars in manual mode, with a mission specialist sitting behind the wheel and manually controlling the vehicle at all times,” Uber said in a statement announcing the new testing in Pittsburgh, Pennsylvania.”While we are eager to resume testing of our self-driving system, we see manual driving as an important first step in piloting these safeguards.”The testing will enable Uber to gather data on different scenarios that will be recreated in computer simulations, and also develop more accurate mapping for the vehicles.Uber suspended its autonomous driving testing in several locations in the United States after the March accident in Arizona that killed a pedestrian.The National Transportation Safety Board said in a preliminary report in May that the car’s sensors detected the pedestrian six seconds ahead of the crash but failed to activate emergency braking.The NTSB said Uber’s engineers had disabled an automatic emergency braking system “to reduce the potential for erratic vehicle behavior.”The pedestrian was dressed in dark clothing and was pushing a bicycle that had no side reflectors when she crossed a unlighted section of roadway.Uber said that in the new tests in Pittsburgh, the self-driving vehicles will have a driver-monitoring system “to help ensure mission specialists are remaining attentive behind the wheel.”The system will send an audible alert if it detects driver inattention.Uber said its automated collision avoidance systems will remain enabled during manual driving—activating emergency braking when it detects a potential accident. Explore furtherlast_img read more

Broadcaster urges football authorities not to leave market to criminals

first_img © 2018 AFP Explore further British regulations prevent live football from being shown between 2:45 pm and 5:15 pm local time on a Saturday in a bid to avoid hurting match attendance figures.Eleven Sports, which holds the UK and Irish rights to La Liga and Serie A, said it would no longer show matches during the blackout period “out of respect for the wishes of our partners”.But it said in a statement: “We maintain our strong view that the rule, which dates back to the 1950s, is unfit for the modern, digital era—particularly for overseas games which we hold the rights to.”And the streaming service, which said the football associations of England, Scotland and Montenegro were the only ones to apply the rule, said the blackout was one of the biggest generators of piracy in the UK.”These games are very easily accessed on illegal sites online and it is naive to think that fans do not watch them because they are not shown on legitimate platforms, except betting sites,” it said.”It is irresponsible to leave the market in the hands of criminals.”Eleven Sports chief executive Marc Watson recently told AFP that piracy poses an existential problem for broadcast rights holders.The company said fans should have access to the games through the official rights holder as they do all over the world but said “intense pressure” from stakeholders within the football establishment” meant they did not have the option. Piracy threatens future of sports broadcasting This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Citation: Broadcaster urges football authorities not to leave market ‘to criminals’ (2018, October 17) retrieved 17 July 2019 from https://phys.org/news/2018-10-urges-football-authorities-criminals.html Broadcaster Eleven Sports says it will no longer show matches during the Saturday afternoon football blackout in the UK but has urged authorities not to leave the market “in the hands of criminals”. British regulations prevent live football from being shown between 2:45 pm and 5:15 pm local time on Saturdays in a bid to avoid hurting match attendance, and Eleven Sports has agreed to honor the blackout periodlast_img read more

Amazon Google agree to allow each others streaming apps

first_imgAmazon and Google announced Thursday they had agreed to allow each other’s streaming media applications to work on their platforms, ending a spat over video between the tech giants. Users of Amazon’s Fire TV will be able to use the YouTube application and Google Chromecast users will have access to Amazon Prime Video under an agreement by the two tech giants The companies said in a statement that the official YouTube apps will be available on Amazon’s Fire TV in the coming months, allowing users of the Amazon platform to access the music videos, movies, shows and other content from the Google-owned service.The agreement also enables Amazon Prime members streaming to Chromecast or using Android TV devices to access Amazon’s video content.The deal appears to end a spat between the two tech giants that made it difficult or impossible for users of one of the video services to use the platform to access the other’s.”We are excited to work with Amazon to launch the official YouTube apps on Fire TV devices worldwide,” said Heather Rivera, head of product partnerships at YouTube.”Bringing our flagship YouTube experience to Amazon Fire TV gives our users even more ways to watch the videos and creators they love.”Andrew Bennett, head of business development for Prime Video, aid the agreement would “give our customers convenient access to the shows and movies they love… customers will have even more ways to stream what they want, whenever they want, no matter where they are.”Amazon and Google are in fierce competition over streaming, but their spat had sparked concerns of anti-competitive conduct by locking out an important rival.The joint statement said Fire TV users will be able to sign in to their existing YouTube account and access their full library of content.Chromecast users will meanwhile have similar access to the Prime Video catalog. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img © 2019 AFP Citation: Amazon, Google agree to allow each other’s streaming apps (2019, April 18) retrieved 17 July 2019 from https://phys.org/news/2019-04-amazon-google-streaming-apps.html Amazon to ban sale of rival video streaming deviceslast_img read more

Serena and Halep chase milestones in Wimbledon final

first_img Tennis 09 Jul 2019 Tennis-Wimbledon day eight Tennis 09 Jul 2019 Factbox: Serena Williams versus Alison Riske Halep said if she dwelt on Williams’ records over the past 21 years it might be game over before she stepped on court for a contest compatriot and gymnastics great Nadia Comaneci said would be “watched by every Romanian alive on the planet”.”I will focus on myself. I’m not thinking about her record. Her records are huge already. It’s nothing about that. It’s just a tennis match, big challenge, a great match. So I will try just to give my best,” said Halep, who has lost just one set so far.A quick study of their rivalry would also suggest Williams will probably be the one holding aloft the Venus Rosewater dish considering she has won nine of their previous 10 meetings. The 27-year-old Halep’s only victory over Williams was almost five years ago, while the American has won all three of their Grand Slam clashes, including at Wimbledon in 2011.So which memory from those tussles will Williams rely on as she gets ready for what could be one of the most memorable days in the history of women’s tennis? BIGGEST KEY”The biggest key with our matches is the (6-0 6-2) loss that I had. I never forgot it,” said the 11th seed, who is also bidding to become the first mother to triumph at Wimbledon since Australian Evonne Goolagong beat American Chris Evert in 1980. “She played unbelievable. That makes me know that… she can get there again. So I have to be better than that.”There’s so many impressive things about her. Obviously her tenacity, her ability to find power. Can’t underestimate her. She’s like a little powerhouse. I feel like she’s back. She wants to prove that she can do it again.”Halep will also take heart from their battle at this year’s Australian Open being a close one and the fact that she has more than just an A-game in her repertoire.”I have a better game these days. I can play everywhere, against anyone. When I go on court… I know how to change some things when (other things) don’t work very well,” said the 2018 French Open champion. “Now, I believe that I have my chance to win against her. I respect a lot what she has done and what she’s doing. But I feel mentally stronger facing her.”A ‘Plan B’ or even ‘Plan C’ could come in handy for Halep as Williams was at her devastating best in a 59-minute destruction of unseeded Czech Barbora Strycova in the semi-finals. Moving as smoothly and striking the ball as crisply and as powerfully as at any time in her career, the American has so far unleashed 45 aces and won 83 percent of her service games. Playing mixed doubles with Andy Murray, albeit in a losing cause this week, has also helped her to sharpen her volleys – an ominous sight for anyone on the opposite side of the net.Williams has already had two failed attempts in finals to win that 24th major – after contesting last year’s Wimbledon and U.S. Open showpiece matches – and, regardless of what she says, everyone knows the American wants that record. “I just trained and I trained and I trained to get physically more fit. So I’m definitely at a different place,” said Williams.”It’s really not about 24 or 23 or 25. It’s really just about going out there and giving my best effort no matter what. No matter what I do, I will always have a great career.” (Reporting by Pritha Sarkar; Editing by Ken Ferris) Tennis 11 Jul 2019 Factbox: Elina Svitolina versus Simona Halep {{category}} {{time}} {{title}}center_img LONDON (Reuters) – Serena Williams no longer wants to obsess about elusive Grand Slam “number 24” and Simona Halep is desperate to win Wimbledon more than to stop the American reaching that milestone but there will be no place for either to hide in Saturday’s final.No matter who wins the title decider on Centre Court, the one thing for certain is that it will be a historic occasion.The 37-year-old Williams is chasing an eighth All England Club singles crown which would see her match Australian Margaret Court’s all-time record of 24 major singles titles.National pride will be at stake for Halep as she bids to become the first Romanian to win a singles title at the spiritual home of grasscourt tennis. Related News Related Newslast_img read more

Saddened by induction of Congress MLAs into party loyal BJP worker quits

first_img Next Indo-Asian News Service PanajiJuly 13, 2019UPDATED: July 13, 2019 11:25 IST Pranav Sanvordekar’s open resignation letter uploaded to Facebook on Friday has gone viral. (Photo: IANS)Days after re-enrolling into the BJP as part of its nationwide membership drive, a young BJP worker on Friday publicly resigned from the party, directly blaming its decision to induct 10 Congress MLAs – one of whom has been chargesheeted for the rape of a minor – for his exit.Pranav Sanvordekar’s open resignation letter uploaded to Facebook on Friday has gone viral.”I am extremely saddened by the events (which) occurred during the last 2 days… I cannot be a part of this organisation anymore even if the decision is for the betterment of the party… If I keep quiet now, it would be like suffering thousand deaths which I already have… The party may have succeeded in safeguarding the interest of the government,” Sanvordekar said in his Facebook message.Sanvordekar has been with the BJP for 18 years and was a part of the state BJP’s communication cell, regularly present at media briefings and issuing communications on behalf of the BJP.Since Wednesday’s surprising induction of 10 Congress MLAs into the BJP, several party workers like former state president and Speaker Rajendra Arlekar, even senior state leaders have already expressed disgust at the development.Late Chief Minister Manohar Parrikar’s son Utpal too has maintained that the Goa BJP was walking on a different path, compared to the days when Parrikar was alive and there was no element of trust left.Sanvordekar said he began his career in the BJP in 1999 writing election slips, and painting roads with BJP insignia. But added that a lot had changed within the BJP since.”Have been defending the wrong doings of the party publicly but had been fighting out internally been even when Manohar bhai was alive and after his demise…” he said.Sanvordekar told IANS that one of the newly-inducted ex-Congress MLAs Atanasio Monserrate, who was chargesheeted for raping a minor girl last year, should be sacked from the party.Monserrate, who contested the May 2019 bypolls for the Panaji seat on a Congress ticket and had defeated the local BJP candidate, is now tipped to be a minister in the Pramod Sawant-led Cabinet.READ | Goa CM Pramod Sawant seeks resignation of 3 ministers, independent MLA to induct new facesALSO READ | Kumaraswamy wants floor test, SC asks Speaker to not act on resignations | All that happenedALSO WATCH | Karnataka crisis: BJP denies poaching chargesFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byKritika Bansal Tags :Follow BJP Saddened by induction of Congress MLAs into party, loyal BJP worker quitsA BJP worker publicly resigned from the party, directly blaming its decision to induct 10 Congress MLAs – one of whom has been chargesheeted for the rape of a minor – for his exit.advertisementlast_img read more