March 11, 1998The ancient ritual of foundry work at Arcosanti.
The world’s leading 100 pay TV services added 5.11 million subscribers in the last quarter of 2014, a rise of 1.42%, according to Informitv’s April Multiscreen Index report.The study said that the 10 ten services with the most subscribers – topped by US operators Comcast, DirecTV and DISH Network – gained 1.65 million subscribers in the last three months of 2014.During full-year 2014, these top 10 services added 5.53 million subscribers and claimed a combined total of nearly 130 million TV customers.“While television services remain a big business, they are part of a broader communications industry in which fixed and mobile broadband services are increasingly important. 2015 is likely to be marked by continuing consolidation as corporations combine their operations to achieve scale in a competitive market,” said Informitv.
Michael LombardoMichael Lombardo is exiting his position as president of programming at HBO, ending a 33-year career at the US premium programmer.Variety broke the news over the weekend, with Lombardo subsequently explaining is decision to rival US trade Deadline. He said he first considered leaving HBO after last year’s Emmy’s, at which it scooped the best drama and best comedy awards for Game of Thrones and Veep.“I recognised that going forward, less and less of my time would be spent developing shows, that I would be spending less and less time with talent and more and more of my job is being a studio executive,” he told Deadline. “I had gotten a taste of being a creative executive, and I was feeling a desire to do more of that.”The HBO programming chief’s departure comes as Game of Thrones continues its run as one of the biggest shows in the world, but cabler’s new series fail to resonate. Period music drama Vinyl has not been a big hit and the second season of True Detective was critically panned. Other new series are reportedly beset with production difficulties.Lombardo has been programming chief at HBO since the high-profile exit of Chris Albrecht in 2007 sparked a restructure.HBO has yet to announce whether there will be a direct replacement for the outgoing exec or who might fill his shoes. Recent changes at the cabler have seen comedy chief Casey Bloys take on drama after the exit of Michael Ellenberg.
Reviewed by James Ives, M.Psych. (Editor)Nov 8 2018The interval at which an individual undergoes a repeat colonoscopy because of previous pre-cancerous polyps — a practice known as “surveillance” — should be tailored to the individual and not simply be determined by the results of prior colonoscopies, according to Regenstrief Institute research scientist Thomas F. Imperiale, M.D. In an editorial in the American Journal of Gastroenterology, he calls for “precision surveillance,” a phrase he has coined to echo the personalized, targeted focus of precision medicine and the application of these concepts to colon cancer screening and surveillance.”The goal of colorectal cancer surveillance is to reduce incidence and death from colorectal cancer,” said Dr. Imperiale. “The only factor we currently consider for whether and when to do a surveillance colonoscopy is the number and size of precancerous polyps found on a previous colonoscopy screening. No other factors are considered; this practice does not always make good clinical sense.”Precision surveillance goes beyond that one element (what’s in the colon) and considers the patient’s phenotype – personal characters such as age, personal medical history, BMI (body mass index), and health habits such as smoking. And when the data become more widely available, consideration of when to rescope should include the skill of the colonoscopists who performed the previous colonoscopies.”Dr. Imperiale says that his editorial, “Thinking Big About Small Adenomas: Moving Towards ‘Precision Surveillance'” is a small step toward advancing surveillance colonoscopy by expanding the proportion of persons considered “low-risk” from one or two small, precancerous polyps to up to four such polyps. The giant leap, he says, would be to employ precision surveillance and make screening recommendations truly personalized and based on the patient, their polyps, and their colonoscopist.Related StoriesAre physical examinations by family doctors still needed?Mosquito surveillance in Madagascar reveals new insight into malaria transmissionScientists discover hundreds of protein-pairs through coevolution studyAlthough studies suggest that the smaller the precancerous lesions are, the longer it takes for them to become cancerous, scientists do not have an accurate picture of the natural history of these lesions because they are removed upon discovery. It is known that most do not become cancerous.”While we want to keep an eye on those individuals who have shown they can grow precancerous polyps, we need to balance being appropriately aggressive in those with whom we should be, with backing off from intense treatment for people who don’t require it ,” said Dr. Imperiale. “Precision surveillance starts to get at that issue.”As an example, he contrasts two hypothetical patients — a healthy 55-year-old and a 70-year-old on home oxygen or dialysis. Each is found to have one or two small precancerous polyps. Current guidelines call for the same five- to ten-year interval for a repeat colonoscopy; most colonoscopists would re-scope at five years. Dr. Imperiale says that colonoscopists need to use their judgment and discuss with each patient when and even if to repeat the colonoscopy.For the 55-year-old he would recommend a repeat colonoscopy in five to ten years or sooner if symptoms appear or other concerns arise. For the 70-year-old with significant health issues he would discuss with the individual and relevant family whether the best course might be to forego further colonoscopy simply to look for any new polyps.”To provide the best care to patients and use healthcare resources responsibly, we need to be more thoughtful about certain factors in addition to the results of previous colonoscopies,” said Dr. Imperiale. “We need to screen and re-examine those who need it most and not those people who won’t benefit. Precision screening and surveillance may help achieve that goal.”Source: https://www.regenstrief.org/article/moving-towards-precision-surveillance/
Source:http://www.asrc.cuny.edu/ Reviewed by Alina Shrourou, B.Sc. (Editor)Feb 28 2019The discovery could lead to novel, more specific, and more effective MS therapies and a better understanding of how the disease developsUnderstanding and mitigating the role of epigenetics (environmental influences that trigger changes in gene expression) in disease development is a major goal of researchers. Now, a newly published paper featured on the March cover of the journal Brain adds significantly to this work by detailing how metabolites can be used to inhibit epigenetic mechanisms and effectively treat a range of diseases, including multiple sclerosis (MS).Dimethyl fumarate (Tecfidera™)–a cell-permeable metabolite in the family of fumaric acid esters (FAEs)–is an approved treatment for MS and is potentially an effective therapy for other autoimmune diseases. The precise mechanism of the drug’s action has been only partially understood, however. In their new paper, researchers at the Advanced Science Research Center (ASRC) at The Graduate Center of The City University of New York and the Icahn School of Medicine at Mount Sinai take a major step toward unraveling the mystery by identifying a possible mechanism of action for FAEs. In doing so, they also highlight new concepts that may lay the groundwork for the development of novel classes of drugs for the treatment of MS and other diseases.Scientists believe that MS develops when epigenetic changes cause certain brain-homing immune cells–or T cells–to attack the central nervous system. In their current paper, researchers posited that FAE metabolites work by mitigating the development of certain brain-homing T cells.”This work has given us extremely useful insight into how we might leverage the metabolic-epigenetic interplay between cells and their environment to create new immune-modulating therapies for diseases like MS,” said Patrizia Casaccia, director of the ASRC Neuroscience Initiative and a professor of genetics and neuroscience at Mount Sinai. “It may one day be possible to target and suppress production of the specific brain-homing T cells that play a role in the development of MS.”MethodologyRelated StoriesMercy Medical Center adds O-arm imaging system to improve spinal surgery resultsNew therapy shows promise in preventing brain damage after traumatic brain injuryRush University Medical Center offers new FDA-approved treatment for brain aneurysmsResearchers recruited 97 volunteers with MS that were either treatment-naïve (47), FAE-treated (35), or glatiramer acetate-treated (16). Blood samples were collected from each participant and their levels of brain-homing T cells were measured by looking at the percentages of the chemokine receptors CCR4 and CCR6, which are critical to T cell trafficking between the gut, brain, and skin. The data showed significantly lower levels of these brain-homing T cells in the FAE-treated group than in the other comparison groups.Researchers subsequently analyzed how FAEs change the epigenetic landscape of T cells to reduce the development of these pathogenic cells. Specifically, they found that FAEs have a strong epigenetic effect on a particular DNA region in T cells that includes a micro RNA called MIR-21, which is necessary to create disease-associated brain-homing T cells. Taken together, the results suggest that the immunomodulatory effect of FAEs in MS is at least in part due to the epigenetic regulation of these specific brain-homing T cells.Significance”Our findings about therapeutically active metabolites have implications for the treatment of not only multiple sclerosis but also other autoimmune diseases such as psoriasis and inflammatory bowel disease, which involve the same type of T cells,” said Achilles Ntranos, lead author of the paper and a physician and neuroimmunology fellow at Mount Sinai Hospital whose work is supported by the Leon Levy Foundation and the National Institute of Neurological Disorders and Strokes. “Understanding the epigenetic effect of metabolites on the immune system will help us develop several novel strategies for the treatment of autoimmune diseases, which could help patients and physicians achieve better clinical outcomes.”Organizational AttributionOur correct name is the Advanced Science Research Center at The Graduate Center of The City University of New York. For the purpose of space, Advanced Science Research Center, GC/CUNY is acceptable. On second reference, ASRC is correct.
© 2018 The Associated Press. All rights reserved. “Adoption of these standards represents a quantum leap in statewide building standards,” said Robert Raymer, technical director for the California Building Industry Association. “You can bet every other of the 49 states will be watching closely to see what happens.”Raymer spoke before the California Energy Commission approved the requirement, alongside new regulations to improve ventilation and indoor air quality. They still need backing from the state’s Building Standards Commission. The state updates its building codes, including energy efficiency standards, every three years.The commission estimates solar panels would boost construction costs for a single-family home by roughly $10,000. But consumers would get that money and more back in energy savings, according to the commission.California has positioned itself as the nationwide leader on clean energy, pushing for more electric vehicles on the roads and fewer emissions from residential and commercial buildings.”This is a very bold and visionary step that we’re taking,” said David Hochschild, one of the energy commission’s five members. In this Oct. 16, 2015 file photo a solar panel is installed on the roof of the Old Governor’s Mansion State Historic Park in Sacramento, Calif. After extensive renovations, Gov. Jerry Brown and his wife, Anne Gust Brown moved into the mansion in late 2015, becoming the first chief executive to live in the home since Ronald Reagan in 1967. The California Energy Commission will take up a proposal, Wednesday, May 9, 2018 , to require solar panels on new residential homes and low-rise apartment buildings up to three starting in 2020. (AP Photo/Rich Pedroncelli, File) In this photo taken Monday, May 7, 2018, solar panels are seen on the rooftop on a home in a new housing project in Sacramento, Calif. The California Energy Commission will take up a proposal, Wednesday, May 9, 2018 , to require solar panels on new residential homes and low-rise apartment buildings up to three starting in 2020. (AP Photo/Rich Pedroncelli) Citation: California regulator OKs solar panels mandate for new homes (2018, May 9) retrieved 18 July 2019 from https://phys.org/news/2018-05-california-oks-solar-panels-mandate.html California moved a step closer Wednesday to requiring solar panels on new homes and low-rise apartment buildings starting in 2020, the first such mandate nationwide and the state’s latest step to curb greenhouse gas emissions. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Representatives from construction groups, public utilities and solar manufacturers all spoke in support of the plan, which they’ve helped the commission develop for years. No industry groups spoke in opposition.But Republican legislative leaders argue Californians can’t afford to pay any more for housing in the state’s already extremely expensive market.”That’s just going to drive the cost up and make California, once again, not affordable to live,” Assemblyman Brian Dahle, the chamber’s Republican leader, said Tuesday.About 117,000 new single-family homes and 48,000 multi-family units will be built in 2020, the commission estimates.The regulations include exceptions when solar panels aren’t feasible—such as on a home shrouded in shade—or cost effective. Installing storage batteries or allowing community-shared solar generation are available options. The requirement would only apply to newly constructed homes, although many homeowners are choosing to install solar panels with the help of rebate programs.”This is going to be an important step forward for our state to continue to lead the clean energy economy,” said Kelly Knutsen, director of technology advancement for the California Solar and Storage Association. Explore further California may require solar panels on new homes in 2020
Google could be ready to dive headlong into video games. The tech giant revealed on Tuesday that it will be holding a special event at the upcoming Game Developers Conference, scheduled for March 18-22 in San Francisco. The notice invites attendees to “gather around” on Tuesday, March 19, at the Moscone Center for a keynote speech.Chatter online about the event pointed to Google’s Project Stream, a PC streaming video game service the company began testing in October and closed last month. Among the games streamed via Google Chrome to computers was Ubisoft’s “Assassin’s Creed Odyssey,” a lush, deep adventure set in ancient Greece.But many also noted that Google could also jump into the hardware game. Back in February 2018, tech news site The Information reported that Google was developing a game streaming service, codenamed “Yeti,” that could on Chromecast or a special Google console.Subsequently, video game news site Kotaku also reported in October that Google was working on some type of hardware solution to go with its streaming platform, as well as looking to acquire or recruit game developers. Google had hired former Sony and Microsoft game executive Phil Harrison in January 2018, the site noted.Regardless, we will know more this time next month. Explore further Credit: CC0 Public Domain Google teams with Ubisoft to test video game streaming This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Google expected to unveil long-expected gaming project at GDC next month (2019, February 20) retrieved 17 July 2019 from https://phys.org/news/2019-02-google-unveil-long-expected-gaming-gdc.html (c)2019 USA TodayDistributed by Tribune Content Agency, LLC.